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KMID : 0861020020170010065
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Korea Journal of Herbology
2002 Volume.17 No. 1 p.65 ~ p.79
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The Effects of Gamgiltang and Kami - gamgiltang on antipyretics , anti - inflammation and discharge of phlegm
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박만석/Park, Man-Suck
손영종/이영종/Son, Young-Jong/Lee, Young-Jong
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Abstract
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Objects : Gamgiltant, which is in common use of laryngopharyngeal disease, consists of Glycyrrhizae Radix and Placotycodi Radix. Author intended to find out the efficacy of Kami-gamgiltant(added Houttuyniae Herba, Schizandrae Fructus and Sterculliae lychnophorae Semen, which are good for respiratory disease, to Gamgiltant) for the purpose of developing a recipe effective for sphagitis or bronchitis.
Methods : After oral administration of Gamgiltang or Kami-gamgiltant to rats, the efficacies of antipyretics, antiinflammation and discharge of phlegm are figured.
After inducing the rats to be feverish by injecting LPS(10㎍ LPS/㎏ body weight) of Serratia marcescens into caudal vein of them, rectal temperatures were taken to prove antipyretic effect.
After inducing the rats to be edematous by injecting 0.1% of carrageenin into hind paw, the volumes of hind paw were measured to prove antiinflammatory effect.
To testify the effect on discharge of phlegm, after administrating the decoctions to rats, quantity of mucous in their throat are measured. Also by aspirating 250ppm of sulfur dioxide 2 and half hours a day during 12 days, rats were induced laryngopharyngeal infections. Then adminstrating the decoction since 5th day of aspiration, the numbers of leukocyte were figured with the object to identify microbial infections.
Results : 1) Gamgiltang and Kami-gamgiltant have antipyretic effects on pyrexia induced by LPS injection. Also the latter recovered quickly than the former. 2) Gamgiltant and Kami-gamgiltang have antiedematous effects on edema induced by carrageenin injection. Also the latter shows a quick recovery than the former. 3) Gamgiltant and Kami-gamgiltang have no effect on normal mucous tissue in their throat. 4) The decoction of Gamgiltang has an effect on inflammation induced by exposure to sulfur dioxide, but the Kami-gamgiltant doesn´t.
Conclusion : Gamgiltang and Kami-gamgiltant could be effective for laryngopharyngeal disease.
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